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By default, directions are calculated and displayed using the unit system of the origin's country or region. (Note: origins expressed using latitude/longitude coordinates rather than addresses always default to metric units.) For example, a route from "Chicago, IL" to "Toronto, ONT" will display results in miles, while the reverse route will display results in kilometers.
The Google Maps API Directions Service returns address results influenced by the domain (region or country) from which you loaded the JavaScript bootstrap. (Since most users load http://maps.google.com/ this sets an implicit domain to the United States.) If you load the bootstrap from a different supported domain, you will get results influenced by that domain. For example, searches for "San Francisco" may return different results from applications loading http://maps.google.com/ (the United States) than one loading http://maps.google.es/ (Spain).